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Voltron Therapeutics, Inc. Initiates Animal Testing of Self-Assembling Vaccine in Fight Against COVID-19

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Animal Trials to Assess the Effect of Novel Vaccine HaloVax™ Against COVID-19
Source: Voltron Therapeutics, Inc.

NEW YORK, July 08, 2020 (GLOBE NEWSWIRE) — Voltron Therapeutics, Inc. announced today it has initiated preclinical animal testing of the first construct of its HaloVax Self-Assembling Vaccine (SAV) against COVID-19. Voltron will take two different vaccines, with differing sets of targets into preclinical testing, in order to identify the best balance of immune responses for prevention of this pandemic pathogen. HaloVax is being developed in conjunction with Hoth Therapeutics, Inc. (NASDAQ: HOTH).

The vaccine is built on a base of a heat shock protein (HSP70) that activates the cellular portion of the immune system; this is different from most other vaccine efforts, which have used adjuvants such as alum. The second portion of the vaccine consists of peptides derived from the COVID-19 virus, which are bound to the heat shock protein via Avidin and Biotin. This enables rapid iteration and up-to-date data informed changes in the peptide sequences to enable swift production and accommodate potential changes in the pathogen itself. The selected immunogenic peptides complete the customized COVID-19 vaccine.

Dr. Mark Poznansky, Director, Vaccine and Immunotherapy Center, MGH said, “The heat shock protein that is the immune activating component of our vaccine has shown efficacy in facilitating a productive immune response while minimizing mechanisms known to induce adverse reactions to a vaccine. Our goal is to rapidly develop and test a vaccine that could help the population at large, and especially individuals who are at increased risk for the most serious complications of COVID-19 infection. Preclinical testing begins here and the fact that prior animal testing of our vaccine platform in the context of other infections has been successful increases the probability of success with our new COVID-19 vaccine.”

The vaccine is currently in development by HaloVax, LLC a biopharmaceutical company and special purpose subsidiary of Voltron Therapeutics, Inc. The company was established to advance an application of VaxCelerate, the SAV platform licensed from the Vaccine and Immunotherapy Center (VIC) at Massachusetts General Hospital (MGH) specifically for the rapid development of vaccines against emerging pathogens including COVID-19 and specific types of cancer. The VaxCelerate platform was developed to improve patient outcomes by activating and targeting the immune system to identify and destroy the infectious agent. Voltron Therapeutics, Inc. has acquired an exclusive worldwide license to this technology from MGH.

“Our team has worked tirelessly to bring HaloVax into preclinical testing, as we continue the development and, potentially, deployment of a vaccine that will not only prevent disease, but will offer safe administration with a strong immune response,” said Pat Gallagher, Chief Executive Officer, Voltron Therapeutics, Inc. “We are quite optimistic that given the kind of safety profile we are targeting in the development of HaloVax, that successful preclinical testing will rapidly lead to clinical trials in humans and bring us closer to a proven and effective vaccine to help treat COVID-19 infection.”

About Voltron Therapeutics, Inc.
Voltron Therapeutics, Inc., a Delaware corporation, was founded in 2017 to lead and accelerate the development of the Vaccine and Immunotherapy Center (VIC), and the Massachusetts General Hospital’s novel Self Assembling Vaccine technology in a variety of indications, including in Oncology and emerging Infectious Diseases. Voltron holds an exclusive worldwide license to this technology. With the work of our world class team of researchers and physicians, this technology has shown in certain pre-clinical studies initial proof of concept in two infectious diseases (Lassa Fever and Q Fever) as well as two oncology indications (Ovarian and HPV Related Cancers). For more information please visit www.voltrontx.com.

About HaloVax™, LLC
HaloVax, LLC is a special purpose subsidiary of Voltron Therapeutics, Inc. in joint venture with Hoth Therapeutics, Inc. (NASDAQ: HOTH) The mission of HaloVax is to develop a novel, Self-Assembling Vaccine against COVID-19, utilizing technology licensed by Voltron Therapeutics, Inc. from the Vaccine and Immunotherapy Center at the Massachusetts General Hospital. The vaccine is being designed from a validated platform to provide customized T cell immunity against COVID-19, as well as be able to adapt rapidly to potential genetic drift of the virus. For more information, please visit www.HaloVax.com.

About Hoth Therapeutics, Inc.
Hoth Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on developing new generation therapies for dermatological disorders. Hoth’s pipeline has the potential to improve the quality of life for patients suffering from indications including atopic dermatitis, chronic wounds, psoriasis, asthma and acne. To learn more, please visit www.hoththerapeutics.com.

Forward Looking Statements
This press release includes “forward-looking statements” within the meaning of the Private Securities Litigation Reform Act of 1995. Forward-looking statements in this press release include, but are not limited to, statements that relate to the advancement and development of the VaxCelerate Platform, the commencement of clinical trials, the availability of data from clinical trials and other information that is not historical information. When used herein, words such as “anticipate”, “being”, “will”, “plan”, “may”, “continue”, and similar expressions are intended to identify forward-looking statements. In addition, any statements or information that refer to expectations, beliefs, plans, projections, objectives, performance or other characterizations of future events or circumstances, including any underlying assumptions, are forward-looking. All forward-looking statements are based upon Voltron’s current expectations and various assumptions. Voltron believes there is a reasonable basis for its expectations and beliefs, but they are inherently uncertain. Voltron may not realize its expectations, and its beliefs may not prove correct. Actual results could differ materially from those described or implied by such forward-looking statements as a result of various important factors, including, without limitation, market conditions and any Voltron filings made with the Securities and Exchange Commission. Consequently, forward-looking statements should be regarded solely as Voltron’s current plans, estimates and beliefs. Investors should not place undue reliance on forward-looking statements. Voltron cannot guarantee future results, events, levels of activity, performance or achievements. Voltron does not undertake and specifically declines any obligation to update, republish, or revise any forward-looking statements to reflect new information, future events or circumstances or to reflect the occurrences of unanticipated events, except as may be required by law.

Media Contact:

Matt Pennacchio
516-851-4766
pennacchio@sunshinesachs.com

Investor Contacts:

Matt Duffy
President
Voltron Therapeutics, Inc.
646-335-5923
mduffy@luciuspartnersllc.com

Jason Assad
Voltron Therapeutics, Inc.
Investor Relations
678-570-6791
jwassad@bellsouth.net

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